Instituto de Medicina Tropical of University of Sao Paulo (IMTSP)

Instituto de Medicina Tropical of University of Sao Paulo (IMTSP) has inter-institutional postgraduate pathology programs across Brazil, and close interactions with the Faculdade de Medicina, USP.

Team Members

  • Hiro Goto

    Hiro Goto

    Associate Professor of Medical Faculty at University of Sao Paulo
    More About Goto

    Hiro Goto is Associate Professor of Medical Faculty of University of Sao Paulo (USP) and develops research at the Institute of Tropical Medicine of Sao Paulo, USP, Brazil. She has degree in Medicine (1972) and Ph.D. (1988) from USP and did post doc at the Department of Immunology, Karolinska Institute, Sweden (1990 – 1993). For over 25 years has been working with leishmaniases, neglected tropical diseases, mostly translational researches. Her area of interest is immunopathology of human and experimental leishmaniases and diagnosis of human tegumentary leishmaniasis and human and canine visceral leishmaniases. She has over 60 articles and reviews in international journals (p.ex. Proc. Natl. Acad. Sci USA, American J. Trop. Med. Hyg, Clin. Infect. Dis., Int. J. Parasitology). The present research lines in immunopathology focus non-specific elements such as lipoprotein fractions, insulin-like growth factor-I in Leishmania infection development, immunopathological mechanisms of lesions in experimental leishmaniasis, susceptibility gene polymorphism and lipid-related factors in subjects in endemic areas of visceral leishmaniasis. In diagnosis, she worked within the network of WHO on diagnosis of visceral leishmaniasis, and presently is developing assays to improve diagnosis of leishmaniases using recombinant Leishmania antigens. For studies on human tegumentary and canine and human visceral leishmaniases maintains collaborations with institutions in endemic areas.

Publications

  • Decreased Frequency and Secretion of CD26 Promotes Disease Progression in Indian Post Kala-azar Dermal Leishmaniasis. Mukherjee S, Mukhopadhyay D, Ghosh S, Barbhuiya JN, Das NK, Chatterjee M. J Clin Immunol. 2016 Jan;36(1):85-94. doi: 10.1007/s10875-015-0215-8. Epub 2015 Dec 7
  • Leishmania infection in blood donors: A new challenge in leishmaniasis transmission? França AO1, Pompilio MA2, Pontes ERJC3, de Oliveira MP4, Pereira LOR4, Lima RB4, Goto H5, Sanchez MCA5, Fujimori M5, Lima-Júnior MSDC6, Matos MFC7, Dorval MEMC Transfusion-transmitted leishmaniasis has been a concern in regions endemic for the disease. Whether immediate or delayed, the risks posed by this mode of transmission call for careful assessment. The purpose of this study was to detect Leishmania infection in blood donors living in an endemic area and to investigate progression to the disease in these individuals. Immunofluorescent antibody test, enzyme-linked immunosorbent assay, leishmaniasis rapid test, and the polymerase chain reaction were applied to 430 donors in an initial evaluation. Of those donors with at least one positive test, 50 were reevaluated four years later by the same methods, as were 25 controls who had been negative on the same tests. In the first evaluation, Leishmania infection was detected in 41.4% (95% CI: 36.7-46.1) of donors (n = 430). None of the 75 reevaluated individuals had developed the disease, but retesting revealed positivity in at least one test in 36.0% (95% CI: 25.1-46.9) of donors. Of the 50 initially testing positive, 50% remained so on retesting. Of the 25 initially negative controls, two tested positive in the subsequent evaluation. The severity of the parasitosis and the risk of transfusion transmission warrant investigation of the potential inclusion of methods for Leishmania detection into blood banks for effective screening of infected donors.
  • Use of Recombinant Antigens for Sensitive Serodiagnosis of American Tegumentary Leishmaniasis Caused by Different Leishmania Species. Sato CM, Sanchez MC, Celeste BJ, Duthie MS, Guderian J, Reed SG, de Brito ME, Campos MB, de Souza Encarnação HV, Guerra J, de Mesquita TG, Pinheiro SK, Ramasawmy R, Silveira FT, de Assis Souza M, Goto H. J Clin Microbiol. 2017 Feb;55(2):495-503. doi: 10.1128/JCM.01904-16. Epub 2016 Dec 7

All Teams